A language model trained on the protein space that generates de novo protein sequences following the principles of natural proteins. The generated proteins display natural amino acid propensities, while disorder predictions indicate that 88% of ProtGPT2-generated proteins are globular, in line with natural sequences. ProtGPT2 is also capable of protein sequence completion.

This app can generate protein sequences of a specified length, while preserving critical functional domains. This make it ideally suited to designing smaller or more compact version of proteins, for gene therapy and other purposes.

Example use case: Designing a novel protein with specific functional properties.

Technology: GPT2

Limitations: Can generate sequences that are too similar to existing proteins or proteins that are not as stable as natural proteins.